Myc regulating cell proliferation and Biology Diagrams Enforced c-Myc expression promotes inappropriate cell cycle progression of growth factor deprived cells and triggers concomitant apoptosis. However, it is not clear what role dysregulation of the cell cycle plays in c-Myc-induced apoptosis. Ornithine decarboxylase (ODC) is a transcriptional target o โฆ
The activation of STAT3 by the cytokine receptor gp130 is required for both the G1 to S cell cycle transition and antiapoptosis. We found that Pim-1 and Pim-2 are targets for the gp130-mediated STAT3 signal. Expression of a kinase-defective Pim-1 mutant attenuated gp130-mediated cell proliferation. Constitutive expression of Pim-1 together with c-myc, another STAT3 target, fully compensated
Myc stimulates cell cycle progression through the activation of Cdk1 ... Biology Diagrams
The role of c-Myc in the cell cycle is further highlighted by the marked prolongation of the doubling time of cells in which both alleles of c-myc were eliminated by homologous Shichiri M, Follansbee M R, Sedivy J M. Effects of c-myc expression on cell cycle progression. Mol Cell Biol. 1994;14:5748-5755. doi: 10.1128/mcb.14.9.5748.
We further show that heterogeneity in c-Myc dynamics leads to variable target gene transcription and that timing of c-Myc expression predicts cell-cycle progression rates and drug sensitivities. Together, our data advocate for a model in which cancer cells increase the heterogeneity of functionally diverse transcription factors such as c-Myc to
Myc and cell cycle control Biology Diagrams
Effects of c-myc expression on cell cycle progression. K D Hanson. K D Hanson. 1 Department of Molecular Biophysics, Yale University School of Medicine, New Dean M., Sonenshein G. E. Cell-cycle control of c-myc but not c-ras expression is lost following chemical transformation. Cell. 1984 Feb;36(2):241-247. doi: 10.1016/0092-8674(84)90217 We will review here the role of MYC as cell-cycle brake releaser i.e., how MYC stimulates cell cycle mainly through the repression of cell-cycle inhibitors . Cell-cycle progression is regulated by serine/threonine protein kinases composed by a catalytic subunit or CDK (cyclin-dependent protein kinase), and a regulatory subunit, the cyclin [ 43
